Additionally, on many keyboards (specifically Apple keyboards), you have to hit a modifier key plus the function key. For example, you have to hit Fn + F1 to get F1 because otherwise it's the "Lower LCD Brightness" hotkey. This makes them even less useful.
Not always useful if e.g. you're locked out of the BIOS, the setting constantly auto-resets for no apparent reason, the keyboard is partially broken.
The sad thing is that I've personally experienced all three of these problems. #%^$ whoever decided that the Function keys should be brightness etc by default.
Does Apple not offer Fn Lock? Most keyboards in the last many years seem to be going this way, but it's always easy to switch it off. I certainly press F5 more often than change brightness.