Google Maps says between 5 and 6 hours and 227 miles - doing that in 3.5 hours would be averaging 65mph. Good luck with that, especially when the speed limit on the A9 itself is 60 mph for cars!
The US interstate is probably more comparable with UK motorways.
I can safely do it in good conditions in six hours and I'd consider myself a very experienced driver for that route, having driven from Skye to Glasgow or Edinburgh and back a couple of times a week for years.
The US interstate is probably more comparable with UK motorways.