Most lisps that leverage repl-driven development also have repl integration in the editor itself. So for example, I write my Clojure code with vim as normal, and when I want to run a snippet of code, I highlight what I want to run and execute that snippet in the editor, that communicates with the running repl instance and displays the result in my editor. This way, when I'm done, I simple save the file that has all the code i've evaluated in it already.