> Ivermectin binds to glutamate-gated chloride channels and is used to treat parasite infections, said Joseph Glajch, a consultant in pharmaceutical and analytical chemistry.
> “These two are so far apart,” he said. “If you look at how they interact with the body..., they don’t even go to the same pathways or receptors.”
Almost as if after clinical evidence (sure, arguably week) and a promising mechanism of action (yeah, in silico) a widespread, double blind RCT should have been conducted a year ago...
My question/comment was not intended to spark discussion about the efficacy of ivermectin for covid-19, just confused at the classification of ivermectin as a protease inhibitor. I don't think most doctors, pharmacists, or epidemiologists would think of ivermectin as a protease inhibitor, even with a few in silica studies suggesting protease activity in certain circumstances.
There have been at least 14 RCTs, including double blinded studies. In meta-analysis, "ivermectin was not efficacious at managing COVID-19"[1]. I won't engage further in that discussion.
Yeah the big pharma were so moral they allowed any other company to copy their complex vaccines that needs special cold storage with significant investment they got free from the government also for specialized manufacturing, all this is offered patent free out of the goodness of their hearts! I wonder why smaller companies didn’t take them up on their generous offer?
