You may be an exceptional character: very dumb or smart; maybe too sensitive of too unemphatic; on some strange neurodiversity spectrum; maybe you was raised by a bit too personal parents; maybe you adopted radical or odd ideologies etc., ad infinitum

Or you may live in an exceptional external situation. It can be good (you are a rock star) or bad (many).

Either way, either case or a bad mix of internal and external may wear you out in the long run, and you stop functioning, you burn out, you become depressed.