Apart from the perimeter limit, LGA's runways are also only ~7000ft.
I don't know what Boom's expected runway requirements are, but if they're anything like the Concorde's (>11000ft), there's no way they'll actually be able to take off from LGA.
Edit: At least one source says that Boom's plane requires no less than 10000ft[1].
The LGA perimeter rule already has holes. Denver is allowed, and the rule doesn't apply on Saturdays. With the much more airline-friendly layout post-construction, it would not be surprising if the rule is changed.
[0]: https://en.wikipedia.org/wiki/LaGuardia_Airport