The limitation for me would simply be the appearance factor; I want my filter to blend in quietly, not to draw attention. I think appearance and noise are part of why people pay so much for fancy purifiers.
Also, I imagine a centrifugal fan would draw less electricity per CFM under load (air resistance through the filter).
Depends how long you run it and on what speed. I seem to remember we were working on the basis of changing it every three months if we ran it continuously during that time
With the same throughput radial fans are much bigger than an axial fan. But they can deliver differential pressures in the range of several 100 Pa, which axial fans cannot.
The limitation for me would simply be the appearance factor; I want my filter to blend in quietly, not to draw attention. I think appearance and noise are part of why people pay so much for fancy purifiers.
Also, I imagine a centrifugal fan would draw less electricity per CFM under load (air resistance through the filter).