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They don't have adjuvants, but they do have lipid nanoparticles which allow the mRNA to breach cells. It's feasible that they could cause unexpected side effects.

NB: I'm personally going to get the first SARS-CoV-2 vaccine I can get, and I'm incredibly excited about mRNA vaccines in general. But, it's true that any time you inject a chemical into your bloodstream you're taking a calculated risk.



FTR, FDA has approved a product (not a mRNA vaccine) using lipid nanoparticles in 2018.

mRNA vaccines had also (limited) human testing before these trials in the past years (mostly Phase 1).


I know. I don't see how it refutes what I said. I'm not anti-vaccine, I was just replying to the parent comment suggesting that because these mRNA vaccines don't use adjuvants they wouldn't have side effects.

All medicines represent calculated risks -- risks that are often worth taking, but still risks.


Please name a vaccine that is injected into your bloodstream.


It's good to see that HN continues to find ways to increase pedantry! You know what I meant, intramuscularly.


“You know what I meant”

No. I am not a mindreader. And “vaccines are injected into the bloodstream” is a standard antivax lie.

Yes there’s a risk in receiving a vaccine, just as there’s a risk in receiving any prophylactic/therapeutic treatment, but severe side-effects are closer to 1-in-100K to 1-in-a-million. Compared to a disease that is currently killing 2-in-100, with significant sequelae likely much higher.

I’m happy to accept that “bloodstream” was a slip of the tongue, but really try not to make those malignant lying bastards’ jobs any easier, when people die because of them.


If you had actually read what I wrote thoughtfully -- instead of falling over yourself to type a glib reply as fast as you could get it out -- it would have been easy to recognize that I am clearly not anti-vaccine, nor was I suggesting that side effects are common. I said both of those things explicitly.

If your goal is actually to educate others, then educate others. Replying with snark achieves nothing but temporarily boosting your own ego.


Yes I read your post, and yes it was poorly worded. Take the tip and move on.




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