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Brain Enhancement Is Wrong, Right? (nytimes.com)
22 points by robg on March 9, 2008 | hide | past | favorite | 67 comments


Academia is different from sports. Despite what many people may think, academia and science are not a game. Your goal is not to be better than someone, but to do good research. If you feel the need to take drugs and you're willing to take its risks, then by all means do. It's not cheating.

Now, requiring people to use substances that might be bad for them is not a good idea. People have to have the freedom to choose if they will take those substances or not. Neither should be mandatory. The reason for this is that we want people to be able to make their own decisions and do whatever pleases them the most; may it be using drugs or not.


Good point. Academia is not a zero-sum game.


Knowledge is not a zero-sum game. Academia, not so much.


Very true. That's a lot more accurate.


Academia is extremely competitive at the professional level,as are many pursuits. That's why many many researchers cheat, and it's so scandalous when they are caught.

Think about this: you lose out on a job opportunity to someone who forged their data or perhaps used stimulants to work at an unnatural pace over a certain period of time. This changes your career in a dramatic way. When that person is caught, what is your compensation? Yes, he (she) was exposed but you were wronged. What would be fair compensation?


It is if there are limited spots for an academic position, papers a journal can publish, etc.


I disagree with this distinction that it's cheating with sports but not academia.

I think what matters is whether there's a health cost to these drugs and if so how much. If a drug is quite safe, then it should be allowed -- no matter whether we are talking about sports or academia.


Since no drug is safe enough for some groups, what really matters is by whom it is allowed. Major league baseball, colleges, and other groups with which people can voluntarily associate seem like reasonable arbiters for their membership's drug use. Governments do not.


Sports are for the entertainment for those watching. The consensus seems to be that the spectators enjoy it more when they know the athletes didn't use any performance enhancing drugs.

Academic research is not done for entertainment, it directly benefits society and mankind in general. If someone wants to risk their health to find a cure for cancer faster, more power to them.


I would be happy and interested to watch a sporting competition in which enhanced humans could compete.

Yes, this would change the focus to "who has the best toys" - but how is this any different from "who was born with the best genes"? To my mind, the element of randomness makes heredity less fair. A striver might be able to get sponsorship for a course of enhancements, but he can't change his birth.


Nascar racing is a sport in which enhanced humans compete at superhuman speeds. They wear specially developed exoskeletons on the field knows as cars. Its great fun to watch, and a complex set of rules has developed over the years as to which enhancements are allowed and how much.


I would be happy if you could find a sporting competition where humans are not enhanced currently.

There are many known tricks such as blood doping that are almost impossible to prevent, and once a few people start doing it everyone must to remain competitive. A huge number of potential athletes take steroids in high school, before testing begins.

I personally think that we should take care to ban these drugs and practices to people who are still developing mentally and physically, but adults should be allowed to make their own decisions. If Stallone wants to eat barrels of HGH to get huge for Rambo, he should be (legally) allowed.


Spectators like to see new world records.


While I don't agree with you, I see where you're coming from and don't think you deserve negative karma for your post.

Let me play devil's advocate for a moment:

One could perhaps make the analogy to caffeine (as others in this thread already have). Sports and academia alike drink it all the time. This is a drug so generally harmless that we don't even consider it a drug. Who would argue that caffeine gives an unfair advantage? Does it not make sense that a drug with a more pronounced benefit and similarly innocuous side-effects should be accepted?


"Despite what many people may think, academia and science are not a game. "

Wait; all that over/under stuff on the Fields Medal betting is a scam?

Damn.


I offer no judgement, but note that if performance-enhancing drugs become the norm in academia and industry, those who opt not to chemically alter (and perhaps harm) themselves are obviously going to be marginalized.

That's why steroids are a problem in sports. It's not that kids "look up" to Barry Bonds. It's that they're not stupid, and they quickly realize the only way to succeed is to dope.

Staying up all night coding sounds awesome to me. Having 2x focus sounds awesome. When research assures me I'm not going to be clinically depressed for the remainder of my life as a result of medicating, I might even consider taking pills for work. But I'll feel guilty about the future I'm creating for my kids.


I would accept a world where you need enhancement to get ahead, for the same reason I accept a world where you need a phone and a car to get ahead. Some people may grumble, but everyone is better off.



We'd all get a little bit further if child labor were allowed, too.


Personally I'd allow it. There's no huge sector of starving families as in the 19th century. Parents would let their kids take jobs - as work experience and character formation. Plus it would divert the unteachables from an education they merely disrupt.

I know, off topic, just tweaking your nose for such a primly self-righteous response.


Yes, and a corollary is that this doesn't necessarily mean the non doped can just go live easier lives because the doped are doing so much more work. The same thing has been said about most of technological revolutions, but do people live more leisurely, relaxed lives today because of our advances?


>The same thing has been said about most of technological revolutions, but do people live more leisurely, relaxed lives today because of our advances?

Yes. There are now more World of Warcraft players in the US than farmers, thanks to mechanized agriculture. This led to a decrease in hours worked from about 80 to 40.

Mechanized factories led to a similar reduction; service workers tend to work far less than factory workers (spending several hours/day at work, but not working).

The rest of the productivity gains went to increased consumption, which tends to mean a greater quality of leisure (I enjoy playing video games much more than I would enjoy watching Big 3 TV networks in 1950).

Doping may lead to an increase in inequality (i.e., non-doped need to work harder to have the same stuff as the doped), but that's a different matter.


And when we find out that modafinil fucks up some useful neurological chemical pathway, or desensitizes the brain to their natural equivalents; well, that's just the price society pays for innovation.

I mean, all the other chemicals we use to regulate the brain have worked out so well. Most of them haven't even turned out to be carcinogens, yet!

Sounds awesome.


If you don't take pills, it's not your problem. Which is the point I was addressing

Society will benefit from productivity gains. Some individuals might be harmed by a risk they chose to take. The article suggests that those undertaking those risks are intelligent and educated, so it's not even like poor fools are being taken advantage of. What's the problem?


Incorrect: if I don't take pills, and all my competitors do, and they're given a competitive boost that they only pay for when they commit suicide at age 41, it is my problem.


The exact same criticism could be levied against your competitors who have no life and work 80-100 hours/week. I suspect that 100 hour work weeks are also more likely to encourage suicide than concentration pills.

Supposing that brain booster pills are as safe as working 80-100 hours/week between the ages of 22 and 41, would you accept that they should be legal and brought to market?


Nonsense. I'm one of those people with no life --- I have a startup, and I have my family, and that's it. I'm depressed when I'm not working.

It's a totally false analogy. I code and break software for a living. I have a blast. Modafinil and aderrol sound like a blast, too. But 20 years from now, I expect to look back fondly on 80 hour work weeks, the way I look back on 2-hour-of-sleep nights with newborns. Unlike the drugs, those weeks won't have scorched my neurochemical pathways.

You talk as if you have some way of measuring the risk of these drugs, or as if the risk was fantastical. I'm not going to have to sound like a alt-med hippie to disprove that.


So you are harming your competitors by engaging in activities which are potentially risky. Those competitors who can't keep up are harmed, either due to you stealing their clients or because they kill themselves (figuratively) trying to keep up. I have a number of friends working in finance who are in such a situation.

I'm not saying I know the risks of these drugs. I'm just saying that "my competitors might do it, and then I can't keep up" is a silly argument against them. There are all sorts of "natural" ways you can compete, many of which might be risky or harmful to you. One of those ways is working as hard as you do.

I don't think the risk is necessarily fantastical, though I suspect it is probably low. I simply think people should be allowed to take the risk if they want to.


What it breaks, we will learn to fix.

With tech improving as fast as it is starting to do, the species really does need to take a more gung-ho attitude. Rush into the future, because the harm of the present can best be undone with technologies we don't have yet.


And if it can't?


We can't avoid all problems, so the general strategy we need is to get more knowledge so we can be better at solving unforeseen problems.

And it's not reasonable to fear the unknown on principle. Being "conservative" by avoiding an advance doesn't make sense in isolation. It might cause a problem. It also might solve one. We don't know that. We do know technology is useful.

But "gung ho" doesn't sound right. Sometimes we have a substantive idea about a way an upcoming technology could be dangerous. In that case we should respect and consider that foresight, not just charge forward anyway.

BTW David Deutsch's TED talk touches on this.


Yeah, that's more what I'm getting at. I don't like straight knee jerk conservatism, but sometimes it is a useful instinct and it warns us to count the costs.


IMO revolutionaries are worse than conservatives. They are more destructive. And there's more ways to be wrong than right.

It's a bit like doing rewrites of major production systems. Not a good idea. But of course it's much worse because human culture is more complex than a computer program.

But also like major production systems, we definitely can improve them. Now we just need unit tests for cultures to make refactoring easier.


Plus, most revolutions aren't really revolutionary in idea. They mainly retread tired, broken ground that the "conservative" position was meant to fix. I'd say a significant amount of innovation in the political, social, and philosophical realm is merely forgetfulness.


Want to give a couple edifying examples?

PS Have you read any Edmund Burke? Got an opinion of him?


The odds that modafinil causes permanent harm of any kind seems pretty unlikely to me. Obvious abuse of modafinil to stop sleeping would cause permanent harm, but that seems unlikely. The FDA doesn't have a perfect track record, but they do have standards that mean something.


You mean like with ritalin, or the antidepressants? I don't think your argument sticks.

It feels like regulations do well with medications that science understands. It does not understand modafinil well. What evidence do you have of "the odds" that it causes no permanent harm?


Even with all the free time, people don't seem so happy. Some stats on depression:

http://www.upliftprogram.com/depression_stats.html

(what's with all the pill popping pre-schoolers?)


How is this a corollary? As a result of increased productivity in society, everyone becomes better off. And yes, people today live more leisurely, relaxed lives materially because of increased productivity.


He argued that in academics and sports, increased performance due to chemical abuse will pressure the non abusers to do the same. This is bad if the abuse is bad for the user.

I'm echoing the idea that increased production doesn't necessarily entail increased happiness due to second order effects.

One scenario: a lot of those WoW players can play so much because their parents have worked very hard. But, they play so much because they don't have good relationships with their parents, since their parents spent so much time working hard.

Then there is the issue of whether the level of production is sustainable, and what happens to a society dependent upon such activity if it stops or slows. Also, what kind of class attitudes develop with the societal stratification.


I'm surprised no one's said it yet: Who says you're enhanced?

As far I know, few studies have shown actual improvement in mental or physical performance without serious side effects. I think even the military, which has studied both amphetamines and steroids, has found that the side effects far outweigh the benefits.

As a big baseball fan, I think the current PED controversy is illustrative. Many folks think they're getting a benefit and are willing to go to great lengths for that edge. But it's not clear they're getting anything other than an confidence boost. You wouldn't take the pill if you didn't think it would work or is working. So you keep taking it.

I think the same is true of neurocosmetics. It easier to believe they work. Still, I'd rather take a nap than a pill. And I'm more worried about neuroimplants - in fifty years.


You can responsibly use amphetamine or modafinil without serious side effects. Amphetamine enhances the mental performance of millions of our children and few people seem to be complaining about long term side effects.

The military has studied the use of amphetamine and modafinil in extreme situations. If you go without sleep for three days, there's going to be serious side effects, with or without any drug. I doubt that any of the scientists on stimulants are using it that extremely, which means the side effects are limited.


The Air Force says you are enhanced by amphetamines:

http://www.wired.com/medtech/health/news/2003/02/57434

(The reporter is a little more skeptical. Then again, the military tend to be big users of statistics, so I expect they have some reason to believe this.)


The fighter pilots I've talked to says it only works in heavy doses for short time periods. That doesn't sound very good to me.


I always ask myself: if substance X is supposedly so beneficial, why doesn't the body manufacture it by itself? Or just creates the effect the drug is supposed to create to begin with?


"If substance X is supposedly so beneficial, why doesn't the body manufacture it by itself?"

Well, it does. Many nootropic drugs work either by stimulating the production of, or blocking the absorption of, otherwise normally occurring brain chemicals.

I believe, for example, that methylphenidate (Ritalin) stimulates the production of dopamine, while bupropion (Wellbutrin) blocks dopamine reuptake.

I used to do a fair amount of wetware hacking, and one of the concerns was avoiding the crash that comes when your brain is depleted of one or another chemical.

One path to a better brain, then, is to feed it the material it needs to produce the more interesting (noradrenalin, dopamine, etc.) stuff.


But wouldn't it be trivial for evolution to change the quantities of those chemicals in the brain? Meaning, if other quantities were preferable, evolution would have adjusted those quantities long ago?


Perhaps they just not preferable for reproduction, or the current quantities are simply good enough for evolution's pressures.


Perhaps it used to, and is broken now. Putting the chemical back is fixing it, like a diabetic with insulin.


Why would it be broken, though? It seems with diabetic, at least with type II, Insulin is not necessary, just change the way you eat. Likewise with the brain I would rather know the causes of the problem, than experiment with drugs.


No doubt this is true to an extent - some folks need the assist. But this article is about much more than that. A diabetic doesn't take insulin to get an edge in business or sports or academics.


If all the world were diabetic, the edge would be to the one with the insulin, no?


It's worth noting that caffeine, in proper doses, enhances both physical and mental performance. So be careful of the slippery slope: slide far enough down and you'll kill your cappuccino.


I've heard food can have the similar effects, let's ban that too.


Actually if you read the literature on Provigil, it is much safer than caffeine in two vital ways. It is not a stimulant, whereas caffeine is, like amphetamines. It very specifically and directly affects the brain's chemistry. It is also not addictive, whereas many a coffee-fiend greets the morning, lunch, afternoon, and night with coffee, and woe to he who gets in their way.

The only reason caffeine, and alcohol, and tobacco are viewed differently from MUCH safer drugs is that some people subscribe to illogical belief systems that differentiate between 'old' drugs and 'new' drugs, regardless of the fact that many of the drugs they hate are just as old as the ones they love.


Dr. Chatterjee: "The way this is likely to be framed is: 'Look, we want smart people to be as productive as possible to make everybody's lives better. We want people performing at the max, and if that means using these medicines, then great, then we should be free to choose what we want as long as we're not harming someone.' I'm not taking that position, but we have this winner-take-all culture and that is the way it is likely to go."

Huh? "Winner-take-all culture"? This seems like a moral issue.

I suspect that a lot of human suffering -- or at least missed potential -- is due to our cognitive biases and other mental shortcomings. I suspect there are many leaders, inventors, and researchers who would improve the human condition far more if they could think faster, remember better, and get tired less. Fighting against a drug that could unleash this potential energy and save huge numbers of lives seems immoral.


I think the effects must be weighed. Is it wrong for a molecular biologist to take drugs if it means he can invent a cure for cancer in 5 years instead of 20? I believe one person should be allowed to do whatever they want with their body as long as it doesn't negatively effect other people, and in said example he might die younger but he'll have saved around 114 million people from death.

We're not talking about handing someone over to some evil aliens or they'll murder 114 million innocents. We're talking about someone saying, "My death will be worth saving 114 million people from an early death." I can't fault someone choosing to do that.


Reminds that marijuana is classified as a performance-enhancing drug by many national (NBA) and multi-national sport governing boards


I once had a Carribean taxi driver tell me that marijuana is the only drug (there are some he probably hasn't tried) that you don't have to process or change in any way. You can ingest it directly from the ground for the same effects. Try that with caffeine, chocolate, tobacco, alcohol, cocaine, heroin, etc. And of course, the psychotropics that "enhance" takes that processing to a whole new level.


Heroin is processed opium. Opium comes from poppy seeds, and the processing for that is minimal.

Cocaine is made from the coca plant; the leaves of which can be chewed raw for a similar, but markedly weaker, effect.

I doubt tobacco has to be processed to be smoked.

Psilocybin mushrooms require no processing.

Peyote requires no processing.

Alcohol be found naturally from rotting, fermented fruit fallen from trees. There's a video on Youtube of animals getting drunk from eating it.

I'm sure there are several other plants that will get you high that I'm unaware of. Just thought I'd throw a little knowledge out there for anyone who might be interested.


I didn't say he was right! But it is an interesting observation, to me, because he's mostly right, based on quantities.

Good luck collecting enough poppy seeds. Same deal on the coca leaves, but try eating a mouthful. Same deal there on tobacco. The same logic applies to caffeine, chocolate, and alcohol. The drug is extremely weak in it's natural form so it requires a decent amount of work to get something really psychoactive.

To him, you can simply pull a marijuana bud off a plant, like an apple from a tree, and eat it for the full effect. That's quite a contrast.

Psilocybin and peyote apply but I don't think he's ever had the opportunity, especially since they don't grow like a weed.

His point: Nature has done a pretty remarkable job providing for our physical and mental health. Why muck with that?


Actually plain Coca leaves have been chewed for (insert very long time frame) by people in its native areas for a variety of medicinal and performance enhancing effects.


don't forget about kratom! ;)


Of course it isn't. What a silly idea. Enhancement is always good, that's why it's enhancement and not harm.


Dude your profile is interesting. I have similar interests and similar singularitarian ideas :-)


If you read that article, you'd think that drugs are the only way to enhancing brain performance... I enhance my brain all the time, but with exercise instead of drugs.

The article seems to be based on the premise that unless you take drugs you can't do anything about the performance of your brain, when there's a wealth of research indicating otherwise. Maybe if people didn't have the misconception that intelligence is something fixed and innate, they would actually try to train their brain instead of taking drugs?


Surprised no one has mentioned Erdos yet.

http://en.wikipedia.org/wiki/Paul_Erdős




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